The Technology

Doxil® and Ayana LC101 – Doxorubicin in Liposome

Supports better localization at the tumor site, concomitantly with lower exposure of normal healthy tissues and organs. Thereby Prevents Cardiotoxicity – the major toxicity effect of doxorubicin, while selectively releases doxorubicin at the tumor site, enabling therapeutic efficacy.

Cryogenic transmission electron micrograph of Doxorubicin HCL Liposome Injection

Suspension at X600,000 magnification

Illustration of the structure of Doxil® and Ayana LC-101 as determined by our small and wide angel X ray scattering analyses:

1 ml of the Doxil dispersion contains 2.3×10^¹⁴ liposomes and each liposome contain ~10000 molecules of doxorubicin, above 95% of it is in the crystalline form

The head-groups of HSPC and the phosphoethanolamine moiety of the DSPE-PEG are shown in blue and their acyl tails are drawn in red, PEG chains are in cyan, cholesterol molecules are in turquoise, and the unit cells of doxorubicin are shown in bourdeaux. The illustration is drawn to scale as indicated by the scale bar and was created by Einav Raviv. (Schilt et al BBA 2015)